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A block in the formation of primitive alveoli in the absence of both p21 and p57. (A) H&E-stained transverse sections of lungs derived from E16.5 (a–e) and from E18.5 embryos (f,g). (B) Expression of p21 and p57 in the lung of E18.5 embryos. (a) CC10 expression detected with in situ hybridization; (b) immunofluorescence staining of p57; (c) p21 expression detected with in situ hybridization. Scale bars, 200 μm.
