Table 1.
CAN1 mutation rates in msh2Δ1 mutants
| Genotype | CanR Rate (× 10−7) | Relative to WT |
|---|---|---|
| wild type | 1.8 (1.4–2.2)a | 1.0 |
| msh2Δ1 | 2.7 (2.3–3.1) | 1.5 |
| msh3Δ | 3.0 (2.2–3.9) | 1.7 |
| msh6Δ | 25.4 (22.3–28.7) | 14.1 |
| msh2Δ | 48.8 (43.9–53.9) | 27.1 |
| pol3-01 | 77.2 (69.3–85.4) | 42.9 |
| rad27G67S | 18.4 (15.7–21.3) | 10.2 |
| msh6KQFF→AAAA | 4.4 (3.0–5.9) | 2.4 |
| msh2Δ1 pol3-01 | 229.2 (218.7–240.0) | 127.3 |
| msh2Δ1 rad27G67S | 28.9 (26.8–31.1) | 16.1 |
| msh2Δ1 msh3Δ | 4.4 (3.5–5.4) | 2.4 |
| msh2Δ1 msh6KQFF→AAAA | 5.7 (4.9–6.5) | 3.2 |
| msh3Δ msh6KQFF→AAAA | 4.8 (4.0–5.7) | 2.7 |
| msh2Δ1 msh3Δ msh6KQFF→AAAA | 11.8 (10.4–13.2) | 6.6 |
a
Canavanine assays were performed as described in the Materials and Methods. Strains used in these studies are shown in Table S1. 95% confidence intervals are in parentheses.