Figure 5. Cavoxin regulates vascular tone in an eNOS- and Cav-1–dependent manner.

(A) Cavnoxin reduces vascular tone in WT vessels. Aortic rings from C57BL/6 mice were incubated with Cavnoxin overnight in organ culture and isometric tension responses to KCl and PE examined in myographs; n = 20 rings from 5 mice. Aortae were isolated from Cav-1 (B) or eNOS-KO (C) mice pretreated with Cavoxin or AP as above. Both KCl- and PE-induced tension changes were assessed as above. Data are mean ± SEM, with 4 rings per mouse and 4–5 mice per group.