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. 2011 Aug 15;121(9):3442–3455. doi: 10.1172/JCI45390

Figure 8. miR-107 is overexpressed in human breast cancer tissues and is related to poor prognosis.

Figure 8

(A) Expression of miR-107 in normal/tumor portions of breast cancer tissues. We isolated RNAs from paired tumor and nontumor samples. Expression of miR-107 was detected by qRT-PCR. The level of miR-107 in nontumor tissue was used as a reference (= 1), and the relative fold expression in the tumor tissue was determined. (B) The correlation between miR-107 and let-7a levels in human breast cancer tissues. qRT-PCR was used to detect expression of miR-107 and let-7a. Each point on the graph corresponds to the relative expression levels from an individual patient. We normalized let-7a and miR-107 levels with U6 to calculate their relative expression levels. We used the averaged expression level of all patients as cutoff value. (C and D) miR-107 level predicts poor clinical outcome in patients with breast cancer. The log-rank test (2-sided) was used to compare differences between groups. The Kaplan-Meier curves show analyses of disease-free (C) and overall (D) survival in patients with breast cancer. (E) Working model of the miR-107–let-7 interaction during cancer progression. Data are presented as mean ± SD.