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. 2011 Aug 25;121(9):3713–3723. doi: 10.1172/JCI45472

Figure 5. Effect of the head artery insulin infusion protocol on net hepatic glucose flux parameters.

Figure 5

(A) Euglycemic conditions. (B) Suppression of NHGO in the HI group was blocked in the HI+LY group. (C) NHGNG flux was unaltered by head insulin. Basal NHGNG flux rates: CTR, 0.57 ± 0.01 mg/kg/min; CTR+LY, 0.85 ± 0.07 mg/kg/min; HI, 0.98 ± 0.10 mg/kg/min; HI+LY, 0.91 ± 0.04 mg/kg/min. (D) The decrease in NHGO in the HI group was entirely a result of decreased NHGLY flux. Basal NHGLY flux rates: CTR, 0.56 ± 0.12 mg/kg/min; CTR+LY, 0.86 ± 0.08 mg/kg/min; HI, 0.82 ± 0.15 mg/kg/min; HI+LY, 0.51 ± 0.06 mg/kg/min. Values are mean ± SEM. n = 4 (CTR and CTR+LY); 8 (HI); 7 (HI+LY). *P < 0.05, HI vs. all other groups; †P < 0.05 vs. basal period.