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. 2011 Aug 25;121(9):3713–3723. doi: 10.1172/JCI45472

Figure 7. Effect of the head artery insulin infusion protocol on cellular indices relevant to gluconeogenesis.

Figure 7

(A and B) Phosphorylation of liver Akt (A) and liver FOXO1 (B) were not different between groups. (C–F) The HI group demonstrated increased phosphorylation of hypothalamic Akt (C), increased phosphorylation of hepatic STAT3 (D), decreased PEPCK, G6Pase, and PC mRNA expression (E), and decreased levels of PEPCK and PC protein (F); these effects were all blunted in the HI+LY group. Values are means ± SEM. n = 4 (CTR and CTR+LY); 8 (HI); 7 (HI+LY). *P < 0.05 vs. all other groups.