Figure 1. Survey of drug effects on the OKR.

Drugs were delivered by i.p. injection at the doses listed in Supplemental Tables 1 and 2. (A–C) Medicinal and miscellaneous psychoactive compounds. (A) Representative 90-second OKR responses to 30 seconds of rotating black and white stripes, preceded and followed by 30 seconds of a uniform gray. Visual stimuli are represented schematically at the top of each panel. Scale bar: 0.5 mm. (B) Four-minute OKR record with continuously rotating black and white stripes after i.p. injection of 2 g/kg ethanol as a 25% ethanol solution in PBS, i.e., equivalent to a blood alcohol level of approximately 0.2%. Scale bar: 1 mm. (C) Quantification of ETM₃₀ during the moving stimulus interval. (D–F) Drugs of abuse and related compounds. (D and E) Representative 90-second OKR records and their quantification, as described for A and C. Scale bar: 0.5 mm. (F) Rotarod performance. For this and all other rotarod experiments, mice were given the same drug doses as shown for the OKR. In most cases, mice were tested immediately after OKR testing. Rotarod performance is quantified as the time to fall off a cylinder rotating at 7 revolutions per minute. Trials were terminated at 60 seconds. Between 2 and 7 mice were tested per drug. Data are presented as the mean ± standard deviation.