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(A) Induction of ER stress in the TM of C57BL/6J by tunicamycin leads to elevated IOP when compared with vehicle control (DMSO). n = 12 for each group. ***P < 0.005 versus control. Data are shown as mean ± SEM. (B) Increased ER stress markers including Grp78, Grp94, Chop, and pelF-2α were detected in the iridocorneal angle tissues of tunicamycin-injected mice by Western blot (n = 4).
