Table 3.

Regimens for the treatment of mono-resistant and poly-resistant strains²⁸

Pattern of drug resistance	Suggested regimen	Minimum duration of treatment in months
H	2RZE and FQ followed by 4–7 R and FQ (FQ = 400 mg moxifloxacin or 750–1000 mg levofloxacin substituted for H in the standard treatment regimen)	6–9
R	2HZE and FQ followed by 10–16 HE and FQ ± injectable for the initial 6 months	12–18
H and Z	RE and FQ	9–12 (longer if extensive disease)
H and E	RZ and FQ	9–12 (longer if extensive disease)
R and E (±S)	HZ and FQ, plus injectable for at least the first 2–3 months (6 months if extensive disease)	18
R and Z (±S)	HE and FQ, plus injectable for at least the first 2–3 months (6 months if extensive disease)	18
H, E, Z (±S)	R and FQ, plus an oral second-line agent, plus injectable for at least the first 2–3 months (6 months if extensive disease)	18

Abbreviations: H, isoniazid; R, rifampicin; E, ethambutol; Z, pyrazinamide; S, streptomycin; FQ, fluoroquinolone.