Table 1.
Control measures in Nrg1, Erbb3, and Erbb4 mouse lines. Data shown are means ± SEM for body weight, percent time in and percent entries into the open arms of an elevated plus maze, total arm entries on the maze, latency to fall from a rotarod (trial 5), latency to find buried food and percent of group finding the food in a test for olfactory ability
| N | Body weight (g) | %Open arm | Total entries | Rotarod latency (s) | Olfactory test | ||||
|---|---|---|---|---|---|---|---|---|---|
| Time | Entries | Entries | Trial 1 | Trial 5 | latency (s) | % group | |||
| Nrg1 | |||||||||
| Cohort 1 | |||||||||
| Nrg1+/+ | 10 | 27 ± 1 | 4 ± 1% | 11 ± 2% | 16 ± 1 | 141 ± 25 | 260 ± 21 | 396 ± 120 | 70% |
| Nrg1+/− | 10 | 27 ± 1 | 6 ± 2% | 15 ± 3% | 19 ± 2 | 103 ± 30 | 230 ± 28 | 205 ± 89 | 90% |
| Cohort 2 | |||||||||
| Nrg1+/+ | 16 | 35 ± 1 | 4 ± 1% | 9 ± 2% | 12 ± 1 | 236 ± 17 | 300 ± 0 | 316 ± 90 | 75% |
| Nrg1+/− | 15 | 33 ± 1 | 4 ± 1% | 11 ± 3% | 12 ± 2 | 207 ± 22 | 295 ± 3 | 75 ± 12 * | 100% |
| Erbb3 WT | 10 | 33 ± 2 | 2 ± 1% | 11 ± 6% | 5 ± 2 | 77 ± 11 | 169 ± 17 | 144 ± 85 | 90% |
| Erbb3 cKO | 12 | 25 ± 0* | 0.5 ± 0% | 4 ± 2% | 6 ± 1 | 132 ± 14* | 187 ± 21 | 158 ± 32 | 100% |
| Erbb4 WT | 11a | 34 ± 4c | 22 ± 4% | 25 ± 4% | 25 ± 3 | 110 ± 30 | 240 ± 32 | 172 ± 77 | 90% |
| Erbb4 cKO | 14b | 43 ± 1*c | 30 ± 3% | 29 ± 2% | 31 ± 2 | 61 ± 13 | 234 ± 24 | 474 ± 104* | 57% |
WT wild-type, cKO conditional knockout
a3 males and 8 females
b7 males and 7 females. All other subject numbers are for male mice
cBody weights are given for male mice
*p < 0.05, comparison to wild-type group from same mouse line