TABLE 2.

Univariate and Multivariate Analysis of Prior Pregnancy Losses: Risk for Childhood CNS Tumors for Any Gestational Age and at ≤20 Weeks' Gestation

	All Cases	LGG	HGG	MB	PNET	GCT	Ependymoma
Losses, n	1.0	1.0	1.0	1.0	1.0	1.0	1.0
Prior pregnancy loss at any gestational age
Univariate
1 prior loss	1.04 (0.93–1.16)	0.98 (0.82–1.18)	1.12 (0.88–1.42)	0.97 (0.71–1.31)	1.24 (0.91–1.69)	0.84 (0.52–1.37)	1.25 (0.87–1.80)
≥2 prior losses	1.00 (0.84–1.19)	0.81 (0.60–1.11)	1.33 (0.93–1.90)	0.93 (0.57–1.51)	0.98 (0.56–1.71)	0.75 (0.31–1.82)	1.56 (0.91–2.68)
Multivariatea
1 prior loss	1.03 (0.92–1.15)	1.00 (0.83–1.20)	1.04 (0.84–1.33)	1.07 (0.78–1.47)	1.17 (0.84–1.61)	0.79 (0.47–1.33)	1.21 (0.82–1.78)
≥2 prior losses	1.01 (0.84–1.22)	0.78 (0.56–1.08)	1.22 (0.84–1.77)	0.98 (0.59–1.62)	0.91 (0.51–1.62)	0.78 (0.28–2.16)	1.60 (0.90–2.83)
Prior pregnancy loss at ≤20 wk' gestation
Univariate
1 prior loss	1.04 (0.94–1.17)	1.00 (0.83–1.20)	1.12 (0.88–1.42)	1.02 (0.75–1.40)	1.13 (0.82–1.56)	0.89 (0.55–1.44)	1.23 (0.85–1.80)
≥2 prior losses	0.98 (0.81–1.18)	0.84 (0.60–1.16)	1.14 (0.78–1.68)	0.96 (0.59–1.55)	1.01 (0.57–1.81)	0.64 (0.25–1.68)	1.65 (0.96–2.84)
Multivariatea
1 prior loss	1.04 (0.92–1.16)	1.02 (0.84–1.23)	1.03 (0.80–1.33)	1.14 (0.83–1.58)	1.05 (0.75–1.47)	0.82 (0.49–1.39)	1.20 (0.81–1.79)
≥2 prior losses	0.94 (0.77–1.13)	0.75 (0.53–1.06)	1.07 (0.72–1.60)	1.00 (0.61–1.65)	0.99 (0.55–1.79)	0.79 (0.29–2.18)	1.59 (0.88–2.85)

Unadjusted and adjusted OR (95% CI).

^aAdjusted for birth weight, birth order, race, Hispanic ethnicity, and maternal age.