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. 2011 Sep 7;101(5):1069–1075. doi: 10.1016/j.bpj.2011.08.001

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© 2011 by the Biophysical Society.

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Truncated LIM mutants are not recruited to force-bearing sites. (A) Individual zyxin LIM motifs do not localize to force-bearing sites. Scale bar: 5 μm. (B) Quantification of traction force and GFP-tagged LIM1, LIM2, or LIM3 accumulation (diamonds: LIM1, n_cell = 9; square: LIM2, n_cell = 10; triangles: LIM3, n_cell = 12). (C) Truncated zyxin LIM domains do not localize to force-bearing sites. Scale bar: 5 μm. (D) Quantification of traction force and GFP-tagged LIM12 or LIM23 accumulation (filled circles: LIM12, n_cell = 10; closed circles: LIM23, n_cell = 11). (E) GFP-tagged LIM12 and LIM23 localized to focal adhesions, albeit less robustly than the zyxin LIM domain containing all three LIM motifs (see also Fig. S4).