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. 2011 Sep 7;101(5):1114–1122. doi: 10.1016/j.bpj.2011.07.045

Figure 2.

Figure 2

Cross-bridge scheme for sinusoidal analysis where M is myosin, A is actin, T is MgATP, D is MgADP, and P is phosphate. (Asterisk) Second conformational state. For conceptual purposes, the primary transitions that influence 2πb and 2πc when a myosin isomerization between Pi and ADP release is rate-limiting, are bracketed. See Swank et al. (26) for a full mathematical description of the elementary rate constant's relationship to 2πb and 2πc, and the derivation of 2πb and 2πc from small amplitude sinusoidal analysis.