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Ribbon representation of the structure of ovPrP (residue 126–233), based on a crystal structure (pdb ID 1UW3 (11)). The structure comprises three α-helices (H1–H3), a short antiparallel β-sheet (B), and a disulfide bridge (SS) linking H2 and H3. The residues involved in genetic modulation in sheep scrapie and the engineered fluorescence probe (Trp-221) are labeled.
