Table 2.
The association of immunohistochemical variants and clinicpathological characteristics of 27 cases of ENKTL with tissue sections
| Characteristics | CD4 | P value | CD8 | P value | FOXP3 | P value | |||
|---|---|---|---|---|---|---|---|---|---|
| ≤ 15.28 | > 15.28 | ≤ 54.31 | > 54.31 | ≤ 22.89 | > 22.89 | ||||
| Age | 1.00 | 0.50 | 0.19 | ||||||
| < 60 | 17 (63.0) | 8 (29.6) | 14 (51.9) | 11 (40.7) | 15 (55.6) | 10 (37.0) | |||
| ≥ 60 | 2 (7.4) | 0 | 2 (7.4) | 0 | 0 | 2 (7.4) | |||
| Gender | 1.00 | 1.00 | 0.63 | ||||||
| Male | 15 (55.6) | 7 (25.9) | 13 (48.1) | 9 (33.3) | 13 (48.1) | 9 (33.3) | |||
| Female | 4 (14.8) | 1 (3.7) | 3 (11.1) | 2 (7.4) | 2 (7.4) | 3 (11.1) | |||
| Stage | 0.09 | 0.43 | *0.005 | ||||||
| I-II | 9 (33.3) | 7 (25.9) | 8 (29.6) | 8 (29.6) | 5 (18.5) | 11 (40.7) | |||
| III-IV | 10 (37.0) | 1 (3.7) | 8 (29.6) | 3 (11.1) | 10 (37.0) | 1 (3.7) | |||
| B symptom | 1.00 | 0.24 | 0.44 | ||||||
| No | 11 (40.7) | 4 (14.8) | 7 (25.9) | 8 (29.6) | 7 (25.9) | 8 (29.6) | |||
| Yes | 8 (29.6) | 4 (14.8) | 9 (33.3) | 3 (11.1) | 8 (29.6) | 4 (14.8) | |||
| LDH | 0.21 | 0.70 | *0.05 | ||||||
| Normal | 8 (29.6) | 6 (22.2) | 9 (33.3) | 5 (18.5) | 5 (18.5) | 9 (33.3) | |||
| Elevated | 11 (40.7) | 2 (7.4) | 7 (25.9) | 6 (22.2) | 10 (37.0) | 3 (11.1) | |||
| PS | 0.68 | 0.69 | 0.22 | ||||||
| 0-1 | 12 (44.4) | 6 (22.2) | 10 (37.0) | 8 (29.6) | 8 (29.6) | 10 (37.0) | |||
| 2-5 | 7 (25.9) | 2 (7.4) | 6 (22.2) | 3 (11.1) | 7 (25.9) | 2 (7.4) | |||
| IPI score | *0.03 | 0.71 | 0.13 | ||||||
| 0-1 | 5 (18.5) | 6 (22.2) | 6 (22.2) | 5 (18.5) | 4 (14.8) | 7 (25.9) | |||
| 2-5 | 14 (51.9) | 2 (7.4) | 10 (37.0) | 6 (22.2) | 11 (40.7) | 5 (18.5) | |||
| KPI score | *0.03 | 0.45 | 0.06 | ||||||
| 0-1 | 4 (14.8) | 6 (22.2) | 7 (25.9) | 3 (11.1) | 3 (11.1) | 7 (25.9) | |||
| 2-4 | 15 (55.6) | 2 (7.4) | 9 (33.3) | 8 (29.6) | 12 (44.4) | 5 (18.5) | |||
| PIT score | 0.67 | 1.00 | 0.42 | ||||||
| 0-1 | 11 (40.7) | 6 (22.2) | 10 (37.0) | 7 (25.9) | 8 (29.6) | 9 (33.3) | |||
| 2-4 | 8 (29.6) | 2 (7.4) | 6 (22.2) | 4 (14.8) | 7 (25.9) | 3 (11.1) | |||
| LMP2A | 0.36 | 1.00 | 1.00 | ||||||
| Negative | 5 (20.8) | 4 (16.7) | 5 (20.8) | 4 (16.7) | 4 (16.70 | 5 (20.8) | |||
| Positive | 12 (50.0) | 3 (12.5) | 9 (37.5) | 6 (25.0) | 8 (33.3) | 7 (29.2) | |||
Note: UAT, upper aerodigestive tract; LDH, lactate dehydrogenase; IPI, International Prognostic Index; KPI, Korean Prognostic Index; PTI: Peripheral T-cell lymphoma Prognostic Index; PS: performance status.