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. 2011 Aug 31;6(8):e24334. doi: 10.1371/journal.pone.0024334

Figure 1. Anti-CMV activity and cytotoxicity of artemsinin-derived compounds.

Figure 1

A: Relative luciferase activity of artemsinin-derived dimers (left), deoxy dimer 574, and artemisinin monomers (right). Infected and treated HFFs were collected 72 hpi and washed once with PBS. The lysates were assayed for luciferase activity using the Luciferase Assay Kit (Promega, Madison, WI). B. Chemical structure of analogs of dimer sulfone 4-carbamate 832-4. Depicted are two sulfide carbamate analogs (800-3 and 800-4) and one sulfone 3-carbamate analog (832-3) of sulfone 4-carbamate 832-4. C: Cytotoxicity of ten artemisinin-dimers and five artemisinin-monomers in HFF. HFFs treated with dimers/monomers at the indicated concentrations were collected at 72 and washed once with PBS. The lysates were assayed for cell viability using CellTiter-Glo Luminescent Cell Viability Assay Kit on GloMax®-Multi+ Detection System (Promega) according to manufacturer's instructions.