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. 2011 Sep 7;101(5):1105–1113. doi: 10.1016/j.bpj.2011.07.017

Figure 6.

Figure 6

Possible Ncd mechanochemical cycle. (A) MH of an Ncd dimer in the ADP state binds to the MT (the unbound head is not shown). (B) ADP releases during or after binding to the MT (14). Whether the motion of the neck is initiated by the ADP release (21) or by ATP binding (14) is unclear (marked by “?”). (C) ATP binding leads to travel of the neck to the post-stroke side (14). (D) The MH detaches upon ATP hydrolysis or γ-phosphate release. (E) The unbound MH advances toward the minus end via recovery stroke driven by torsional relaxation and diffusion.