Table 1.

Fixed parameters

Parameter	Source	Reported units	Reported value	Reported margin of error
ADH1 km*B1-C1	[12]	mmol/l	0.13	0.04
ADH1 km*B1-C2	[12]	mmol/l	0.11	0.04
ADH1 km*B2-C1	[12]	mmol/l	1.6	0.1
ADH1 km*B2-C2	[12]	mmol/l	1.7	0.1
ADH1 km*B3-C1	[12]	mmol/l	9.8	3.7
ADH1 km*B3-C2	[12]	mmol/l	15	5
ADH1 vmax*B1-C1	[12]	mmol/min/1.4 kg liver	2.1	0.1
ADH1 vmax*B1-C2	[12]	mmol/min/1.4 kg liver	1.7	0.1
ADH1 vmax*B2-C1	[12]	mmol/min/1.4 kg liver	20	1
ADH1 vmax*B2-C2	[12]	mmol/min/1.4 kg liver	19	1
ADH1 vmax*B3-C1	[12]	mmol/min/1.4 kg liver	7.6	1.3
ADH1 vmax*B3-C2	[12]	mmol/min/1.4 kg liver	8.2	1.4
ADH7 km*l	[4]	mmol/l	2,090	none
ADH7 km*2	none	mmol/l	NA	none
ADH7 vmax*l	[4]	mmol/min/kg0.75	0.0015	none
ADH7 vmax*2	none	mmol/min/kg0.75	0*	none
ALDH2 km*l	[5]	mmol/l	0.4	none
ALDH2 km*2	none	mmol/l	NA	none
ALDH2 vmax*2	none	mmol/min/kg liver	0*	none
DPY TAS2R38*1/*1	[23]	number of drinks per year	132.90	21.98
DPY TAS2R38*1/*2	[23]	number of drinks per year	180.49	29.32
DPY TAS2R38*2/*2	[23]	number of drinks per year	285.16	55.82

Each parameter was fixed at the reported value. v_max values for ADH7 and ALDH2 isoforms reported to be inactive in the literature were not explicitly reported, but inferred to be zero (0^*), in which case the corresponding k_m value was irrelevant or not applicable (NA).