Figure 4. Schematic representation of the SOD3 action in promoting the cell survival in injured tissues.

Temporal simultaneous activation of Erk1/2 and Akt leads to phosphorylation and consequent cytoplasmic translocation of FoxO3a, which then increases miR-21 production and downregulates the bim mRNA expression. Erk1/2 activation further stimulates the cell survival signaling by increasing cell proliferation related transcription factor production.