Table A2.
Characteristics of Patients Undergoing Resection for Stage II/III Colon Cancer After Propensity Score Weighting
| Characteristic | Stage II With No Poor Prognostic Features (n = 6,234) |
Stage II With Any Poor Prognostic Features (n = 18,613) |
Stage III (n = 18,185) |
||||||
|---|---|---|---|---|---|---|---|---|---|
| No Chemo (81%) | Chemo (19%) | P | No Chemo (79%) | Chemo (21%) | P | No Chemo (43%) | Chemo (57%) | P | |
| Patient characteristics | |||||||||
| Age, years, % | .93 | .98 | .99 | ||||||
| 65-69 | 13.0 | 13.1 | 10.6 | 10.7 | 13.4 | 13.3 | |||
| 70-74 | 20.8 | 20.5 | 19.1 | 19.1 | 21.8 | 21.8 | |||
| 75-79 | 25.5 | 25.1 | 24.1 | 24.4 | 25.1 | 25.2 | |||
| 80-84 | 23.1 | 22.3 | 23.2 | 22.9 | 21.6 | 21.7 | |||
| 85+ | 17.7 | 19.0 | 23.1 | 22.9 | 18.1 | 18.1 | |||
| Male sex, % | 43.2 | 47.0 | .10 | 39.6 | 48.2 | < .001 | 40.8 | 43.0 | .02 |
| Race/ethnicity, % | .08 | .07 | < .001 | ||||||
| White | 86.6 | 87.7 | 86.6 | 87.1 | 81.3 | 85.2 | |||
| Black | 5.8 | 3.5 | 6.4 | 5.0 | 9.3 | 5.7 | |||
| Asian or Pacific Islander | 4.1 | 5.0 | 3.4 | 3.4 | 5.1 | 4.9 | |||
| Hispanic or other | 3.5 | 3.7 | 3.7 | 4.5 | 4.3 | 4.2 | |||
| SEER registry, % | .10 | .14 | < .001 | ||||||
| California | 26.5 | 31.7 | 28.7 | 27.3 | 27.0 | 28.1 | |||
| Connecticut | 8.8 | 9.9 | 9.8 | 10.3 | 9.1 | 11.2 | |||
| Detroit | 2.5 | 2.6 | 10.7 | 11.9 | 11.8 | 10.9 | |||
| Hawaii | 12.6 | 10.8 | 1.2 | 0.8 | 2.2 | 1.8 | |||
| Iowa | 2.7 | 2.3 | 14.6 | 13.5 | 12.0 | 12.4 | |||
| New Mexico | 7.5 | 6.4 | 2.3 | 2.3 | 3.1 | 2.6 | |||
| Seattle | 3.4 | 3.2 | 7.4 | 6.5 | 7.0 | 6.5 | |||
| Utah | 4.1 | 3.7 | 2.7 | 2.4 | 3.4 | 3.1 | |||
| Atlanta and rural Georgia | 5.5 | 5.0 | 4.0 | 3.6 | 4.3 | 3.4 | |||
| Kentucky | 4.3 | 5.2 | 4.4 | 5.2 | 5.5 | 4.5 | |||
| Louisiana | 10.5 | 11.5 | 4.3 | 5.2 | 4.6 | 4.2 | |||
| New Jersey | 26.5 | 31.7 | 9.9 | 11.0 | 10.1 | 11.4 | |||
| Marital status, % | .20 | .33 | .80 | ||||||
| Married | 53.1 | 56.9 | 47.4 | 49.5 | 50.6 | 51.6 | |||
| Widowed | 32.6 | 30.7 | 37.5 | 35.2 | 34.0 | 33.4 | |||
| Single, separated, or divorced | 11.2 | 8.7 | 11.9 | 12.2 | 12.5 | 12.1 | |||
| Unknown | 3.1 | 3.7 | 3.1 | 3.2 | 2.9 | 2.9 | |||
| Residence location, % | .02 | .73 | .38 | ||||||
| Major metropolitan | 53.8 | 60.1 | 55.3 | 55.6 | 57.1 | 55.7 | |||
| Metropolitan or urban | 35.5 | 30.6 | 34.0 | 33.2 | 32.8 | 33.6 | |||
| Less urban or rural | 10.8 | 9.3 | 10.7 | 11.2 | 10.2 | 10.7 | |||
| Median household income (census tract), $ in thousands | .07 | .006 | < .001 | ||||||
| Mean* | 46.8 | 48.8 | 44.2 | 44.1 | 43.8 | 45.6 | |||
| 95% CI | 46.1, 47.5 | 46.4, 51.2 | 43.8, 44.6 | 43.0, 45.1 | 43.1, 44.5 | 45.0, 46.2 | |||
| Less than 12 yr education (census tract), % | .97 | .61 | < .001 | ||||||
| Mean* | 18.1 | 18.2 | 19.4 | 19.6 | 20.0 | 19.2 | |||
| 95% CI | 17.8, 18.5 | 17.1, 19.4 | 19.2, 19.6 | 19.0, 20.2 | 19.6, 20.4 | 18.8, 19.5 | |||
| HCC comorbidity score | < .001 | < .001 | < .001 | ||||||
| Mean | 1.7 | 1.8 | 2.1 | 2.1 | 2.6 | 2.6 | |||
| 95% CI | 1.7, 1.8 | 1.7, 1.9 | 2.1, 2.1 | 2.0, 2.1 | 2.5, 2.6 | 2.5, 2.6 | |||
| Tumor characteristics | |||||||||
| Year of diagnosis, % | .12 | .78 | .95 | ||||||
| 1992-1995 | 18.0 | 15.4 | 22.7 | 22.1 | 19.6 | 19.7 | |||
| 1996-1999 | 18.8 | 17.3 | 21.7 | 21.0 | 19.7 | 20.1 | |||
| 2000-2002† | 29.6 | 29.1 | 29.6 | 30.2 | 29.6 | 29.5 | |||
| 2003-2005† | 33.6 | 38.2 | 26.0 | 26.7 | 31.2 | 30.7 | |||
| Tumor location, % | .47 | .10 | .08 | ||||||
| Right colon | 63.9 | 63.4 | 53.7 | 52.9 | 56.3 | 57.8 | |||
| Transverse colon | 10.1 | 8.1 | 11.7 | 9.9 | 10.8 | 9.3 | |||
| Left colon | 8.1 | 9.1 | 10.2 | 10.9 | 9.3 | 8.8 | |||
| Sigmoid colon | 16.3 | 17.9 | 22.9 | 24.5 | 21.9 | 22.2 | |||
| Unknown | 1.6 | 1.5 | 1.5 | 1.8 | 1.7 | 1.9 | |||
| Comorbidity and treatment measures | |||||||||
| Any hospitalization in the previous year, % | 26.4 | 28.0 | .48 | 27.4 | 26.6 | .49 | 26.6 | 26.4 | .79 |
| Rehospitalization within 30 days of discharge, % | 10.8 | 8.2 | .04 | 12.1 | 12.1 | .94 | 11.8 | 12.2 | .47 |
| Any in-hospital surgical complication, % | 2.8 | 2.9 | .92 | 4.1 | 4.4 | .58 | 3.7 | 3.7 | .94 |
| Oncologist visit within 30 days of surgery, % | 28.1 | 27.6 | .80 | 29.7 | 29.9 | .89 | 45.2 | 45.5 | .82 |
| Poor prognostic features | |||||||||
| Emergent admission, % | NA | NA | 25.7 | 23.6 | .07 | 24.1 | 18.8 | < .001 | |
| Intestinal obstruction on admission, % | NA | NA | 6.0 | 6.5 | .31 | 5.5 | 4.7 | .07 | |
| Intestinal perforation on admission, % | NA | NA | 2.4 | 4.1 | < .001 | 2.3 | 1.7 | .03 | |
| T stage, % | < .001 | .16 | |||||||
| Tis, T0, T1, or T2 | NA | NA | 0.0 | 0.0 | 10.2 | 11.2 | |||
| T3 | 0.5 | 0.5 | 82.8 | 74.0 | 70.4 | 70.4 | |||
| T4 | NA | NA | 17.2 | 26.0 | 19.4 | 18.4 | |||
| No. of nodes resected, % | .01 | .32 | |||||||
| 0-11 | NA | NA | 72.5 | 69.7 | 49.8 | 48.8 | |||
| ≥ 12 | 0.5 | 0.5 | 27.5 | 30.3 | 50.3 | 51.2 | |||
| Tumor grade, % | .86 | .05 | .68 | ||||||
| Well differentiated | 0.0 | 0.0 | 7.5 | 7.1 | 5.4 | 5.1 | |||
| Moderately differentiated | 0.5 | 0.5 | 66.7 | 64.2 | 63.9 | 63.6 | |||
| Poorly or undifferentiated | NA | NA | 25.9 | 28.8 | 30.8 | 31.3 | |||
| No. of poor prognostic features, % | < .001 | < .001 | |||||||
| 0 | 0.5 | 0.5 | NA | NA | 21.5 | 22.8 | |||
| 1 | NA | NA | 61.2 | 56.5 | 39.9 | 42.3 | |||
| 2 | NA | NA | 29.7 | 30.6 | 26.7 | 25.3 | |||
| 3 | NA | NA | 7.6 | 10.9 | 9.6 | 7.7 | |||
| 4, 5, or 6 | NA | NA | 1.5 | 2.0 | 2.3 | 1.9 | |||
NOTE. Percentages may not sum to 100% because of rounding.
Abbreviations: Chemo, chemotherapy; SEER, Surveillance, Epidemiology, and End Results; SD, standard deviation; HCC, Hierarchical Condition Categories; NA, not applicable.
*
A total of 2,243 individuals with missing data were not included in these means.
†
Three SEER registries (Kentucky, Louisiana, New Jersey) were added in 2000.