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. 2011 Sep;39(9):1718–1726. doi: 10.1124/dmd.111.039446

Fig. 3.

Fig. 3.

Serum concentration (Conc) versus time curve of AMP from one animal representative of the average pharmacokinetics after an intravenous bolus dose of 1 mg/kg AMP to pregnant rats on GD21 and the serum concentration versus time curves of METH and its metabolite AMP (from Fig. 4) after a 1-mg/kg METH dose on GD21. The best-fit lines for the serum concentration versus time profile of intravenous METH and intravenous AMP (solid line) and AMP metabolite (dashed line) were determined by a noncompartmental model in the terminal elimination phase.