Fig. 4.

Serum concentration (Conc) versus time profile of METH and AMP after intravenous bolus dose of METH at 1, 3, or 5.6 mg/kg in pregnant female Sprague-Dawley rats on GD21. Semilogarithmic graphs were representative of one animal from each group (n = 5 per dose group) that portrays the mean pharmacokinetic values. The best-fit lines for the serum concentration versus time profile of METH (solid line) and AMP (dashed line) were determined by a noncompartmental model in the terminal elimination phase.