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. 2011 Sep;39(9):1718–1726. doi: 10.1124/dmd.111.039446

Fig. 5.

Fig. 5.

Serum concentration (Conc) versus time graph of METH and AMP after intravenous bolus METH (5.6 mg/kg) administration on GD21 to pregnant rats that developed lethal toxicity after METH administration. Top, METH and AMP concentrations for a pregnant rat that died approximately 9 h after METH administration. Bottom, METH and AMP concentrations for a pregnant rat that delivered stillbirths on GD25. The best-fit lines for the serum concentration versus time profile of METH (solid line) and AMP (dashed line) were determined by a noncompartmental model in the terminal elimination phase. These METH and AMP concentrations were compared to the concentrations for the pregnant rat representative of the mean pharmacokinetic values (n = 5) of this dose group shown previously in Fig. 4 (bottom). However, data from these two rats were not included with the surviving, apparently normal rats (n = 5) in the pharmacokinetic data analysis in Table 3.