TABLE 2.

Salivary APAP pharmacokinetics and urinary APAP metabolite excretion by diet and UGT1A6 genotypes within diet

Data are least squares means ± S.E.

	Overall			UGT1A6*1/*1		UGT1A6*1/*2		UGT1A6*2/*2
	Basal	F&V	P*	Basal	F&V	Basal	F&V	Basal	F&V
Salivary pharmacokinetics
n	65	65		27	27	25	25	13	13
Cmax (mg/l)	16.1 ± 0.6	17.5 ± 0.7	0.003	17.2 ± 0.9	18.3 ± 1.0	15.1 ± 0.9	16.0 ± 0.9	16.0 ± 1.3a	18.4 ± 1.5b
Clearance (1/h)	10.0 ± 0.5	9.9 ± 0.5	0.88	9.3 ± 0.7‡	9.5 ± 0.7	11.9 ± 0.9†	10.5 ± 0.8	9.1 ± 1.0‡	9.8 ± 1.1
AUC (mg · min/l)	6103 ± 270	6155 ± 272	0.88	6414 ± 419	6326 ± 408	5378 ± 369	5692 ± 387	6588 ± 613	6478 ± 611
t1/2 (min)	260 ± 15	282 ± 16	0.17	261 ± 22	281 ± 23	245 ± 22	285 ± 25	275 ± 33	279 ± 34
Urinary APAP metabolite excretion
n	65	65		27	27	25	25	13	13
% oral does
%APAP	3.1 ± 0.12	3.2 ± 0.12	0.25	3.37 ± 0.16	3.53 ± 0.16†	2.91 ± 0.16	3.00 ± 0.16‡	2.95 ± 0.23	2.98 ± 0.23‡
%APAPG	35.0 ± 0.9	35.8 ± 0.9	0.17	32.9 ± 1.4	34.7 ± 1.4	35.4 ± 1.4	36.3 ± 1.4	36.7 ± 2.0	36.6 ± 2.0
%APAPS	24.1 ± 0.9	22.1 ± 0.9	<0.0001	25.0 ± 1.3a	23.2 ± 1.3b	25.0 ± 1.3a	22.9 ± 1.3b	22.5 ± 1.9a	20.1 ± 1.9b
Metabolite ratios
APAPG ratioc	56.2 ± 1.2	58.9 ± 1.2	<0.0001	53.5 ± 1.7a	56.7 ± 1.7b	56.1 ± 1.8a	58.7 ± 1.8b	58.9 ± 2.5a	61.2 ± 2.5b
APAPG/APAP*	11.8 ± 0.6	11.9 ± 0.6	0.83	10.0 ± 0.7	10.1 ± 0.7†	12.7 ± 0.9	12.9 ± 0.9‡	13.2 ± 1.3	12.9 ± 1.3‡
APAPS/APAP	8.1 ± 0.4	7.1 ± 0.3	<0.0001	7.5 ± 0.5a	6.6 ± 0.4b	8.7 ± 0.6a	7.9 ± 0.5b	8.1 ± 0.8a	7.0 ± 0.7b

^* Significant overall diet effect for UGT1A6 genotype (P < 0.05).

^†,‡ <ths>Different superscript numbers represent significant genotype differences within diet (P < 0.05).

^a,b Different superscript letters represent significant diet differences within a genotype (P < 0.05).

^c APAPG/(APAP + APAPG + APAPS) × 100.