Fig. 3.

Dorzolamide showed better delivery to the aqueous humor and plasma than that of brinzolamide after multiple topical dosing in pigmented rabbits. Plots show tissue levels of dorzolamide and brinzolamide in the cornea, conjunctiva, aqueous humor, and plasma after multiple topical ocular administration of Trusopt (dorzolamide hydrochloride, 2.0%) or Azopt (brinzolamide suspension, 1.0%). Animals were sacrificed at 1 h after the last dose. Data represent mean ± S.D. for n = 3. *, P ≤ 0.05, significantly different from brinzolamide.