TABLE 3.

Comparison of mean drug levels in ocular tissues after single and multiple topical dosing (42 doses)

Drug levels were assessed at 1 h after the last dose. To assess drug accumulation, ratios of the drug levels between multiple and single dose regimens were calculated. Brinzolamide was not detected in the posterior vitreous after single dose administration.

Tissue	Dorzolamide			Brinzolamide
	Single Dose	Multiple Dose	Multiple Dose/Single Dose Ratio	Single Dose	Multiple Dose	Multiple Dose/Single Dose Ratio
	μg/g	μg/g		μg/g	μg/g
Cornea	10.31	21.4	2.08	7.99	14.1	1.76
Conjunctiva	10.10	5.89	0.60	6.77	4.57	0.68
Aqueous humor	1.49	2.35	1.58	0.530	1.48	2.80
Sclera (anterior)	9.12	7.67	0.85	1.57	4.20	2.60
Sclera (posterior)	0.460	0.56	1.21	0.140	0.57	4.07
Retina (anterior)	1.02	3.00	2.94	0.821	2.30	2.80
Retina (posterior)	0.023	2.10	90.13	0.015	1.30	86.7
Vitreous (anterior)	0.07	0.17	2.43	0.034	0.05	1.47
Vitreous (posterior)	0.0096	0.065	6.80	–	0.029	–
Optic nerve	0.657	0.86	1.31	0.269	0.370	1.38

–, Pharmacokinetic parameters are not available due to undetected drug levels.