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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Mycoses. 2011 May 25;54(6):e877–e879. doi: 10.1111/j.1439-0507.2011.02016.x

Table 1.

Voriconazole pharmacokinetic parameters in case patient and in healthy volunteers

Pharmacokinetic Parameter Voriconazole 405 mg IV every 12h (case patient)* Voriconazole 325 mg IV every 12h (case patient)+ Voriconazole 4 mg/kg IV every 12h (healthy volunteers) (Purkins L et al., Antimicrob Agents Chemother 2002;46:2546–53)
AUC0–12 (ng · h/ml) 77,790 104,245 29,467
Clearance (L/h) 5.01 3.16
Vd (L) 221 101
t1/2 (h) 30 24 7.9
trough (mcg/ml) 6.1 6.7 1.7
*

infusion time (1.75 h); collection time points from beginning of infusion (2.5, 5.6, 9.5, 11.5 h).

+

infusion time (1.5 h); collection time points from beginning of infusion (3.1, 6, 10.2, 12.2 h).

not reported.