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[3 + 2] Annulations with tert-Butyl Carbamate
 | ||||
|---|---|---|---|---|
| entry | aldehyde | yielda | drb | product 2 |
| 1 |
|
67% | >20:1 | 2a |
| 2 |
|
82% | >20:1 | 2b |
| 3 |
|
60% | >20:1 | 2c |
| 4 |
|
50% | >20:1 | 2d |
| 5 |
|
67% | >20:1 | 2e |
| 6 |
|
69% | >20:1 | 2f |
| 7 |
|
58% | >20:1 | 2g |
| 8 |
|
57% | >20:1 | 2h |
| 9 |
|
48% | >20:1 | 2i |
| 10 |
|
33% | >20:1 | 2j |
| 11 |
|
37% | >20:1 | 2k |
Isolated yields after purification over silica gel.
Diastereomeric ratios determined by 1H NMR analysis on crude material.
