Table 3. Allele Frequencies of IL-23 Receptor Pathway and Th-17 Regulatory Lymphocyte Differentiation Pathway Genetic Variants in UC/IBDU and CD.
| Chr | Gene | Assoc IBD Subtype | SNP | Freq in CD n = 1144 |
Freq in UC/IBDU n = 1230 |
Freq in HC n = 1057 |
P-value UC/IBDU vs. CD | P-value CD vs. HC | P-value UC/IBDU vs. HC |
|---|---|---|---|---|---|---|---|---|---|
| 1p31 | IL23R | CD and UC | rs11465804 | 0.0287 | 0.0381 | 0.0567 | P = 0.117 | P = 1.98E-06 | P = 0.001 |
| 1p31 | IL23R | UC | rs10889677 | 0.3841 | 0.3842 | 0.3282 | P = 0.754 | P = 0.0003 | P = 9.54E-05 |
| 5q33 | IL12B | CD and UC | rs10045431 | 0.2542 | 0.2527 | 0.3094 | P = 0.627 | P = 5.39E-05 | P = 6.05E-06 |
| 6q27 | CCR6 | CD | rs2301436 | 0.4860 | 0.4559 | 0.4757 | P = 0.045 | P = 0.551 | P = 0.17 |
| 17q21 | STAT3 | CD | rs744166 | 0.3947 | 0.3760 | 0.4016 | P = 0.136 | P = 0.085 | P = 0.796 |
| 21q22 | ICOSLG | CD | rs762421 | 0.3786 | 0.4142 | 0.3766 | P = 0.015 | P = 0.011 | P = 0.865 |
Chr = chromosome band, CD = Crohn's disease, UC = ulcerative colitis, IBDU = inflammatory bowel disease - unclassified, HC = healthy controls, SNP = single nucleotide polymorphism, Freq = minor allele frequency.
SNPs in bold font, significantly different (P < 0.05) frequencies between CD and UC.