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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Immunity. 2011 May 19;34(5):807–819. doi: 10.1016/j.immuni.2011.03.022

Figure 6. Intravital imaging of Mtb-infected animals reveals limited antigen recognition by p25 T cells.

Figure 6

(A) LysM-EGFP animals were subject to intravital hepatic imaging 2 weeks following i.v. infection with Mtb. See also Movie S5. (B) CMTPX-labeled p25 and CMFDA-labeled OTII T cells were transferred i.v. into mice that had been infected with Mtb 2 weeks earlier and imaged 4 hours later. Scale bars, 50μm. See also Movie S6. (C and D) Quantification of velocity and arrest coefficient for granuloma-associated p25 and OTII T cells in Mtb-infected mice. Data points represent individual cells compiled from at least four separate experiments with median values indicated (P<0.0001 (C) and P=0.0003 (D), Mann-Whitney U-test).