Table 2A.
Review of the Literature
| Reference | No. Cases | Age, y | Sex | Location | Clinical History | Clinical Findings | Pathological Findings |
|---|---|---|---|---|---|---|---|
| Hantelmann15 | 1 | 9 | M | N/A | Hodgkin disease, amyloidosis of liver, spleen, and kidneys | LPH of the pancreas | |
| Hoyer16 | 1 | 9 mo | M | Diffuse | Steatorrhea and weight loss | Lack of exocrine parenchyma, preservation of islets and overcompensation by fat | |
| Lumb and Beautyman21 | 2 | 9 mo; 6 d | F; M | N/A; diffuse | Steatorrhea | F: lipomatous pancreas M: a few minute areas of pancreatic tissue were found lying in fat tissue |
|
| Robson and Scott7 | 1 | 77 | M | Diffuse | Steatorrhea | Swelling of the ankles, legs, abdomen, cerebrovascular incident→Died | Abundance of mature adipose tissue with remnants of pancreas parenchyma |
| Beresford and Owen6 | 2 | 27; 23 | F; M | Both diffuse | F: scleroderma, pulmonary tuberculosis M: celiac disease |
F: →Died M: bronchopneumonia→Ex |
F: fatty infiltration and atrophy of the parenchyma M: fatty replacement of the acini with survival of the islets of Langerhans |
| Salm14 | 1 | 69 | M | Diffuse | Scirrhous carcinoma arising in LPH with widespread metastases and obstruction of the vena cava | ||
| Salm17 | 1 | 71 | F | Diffuse | Gangrene of the toes of the right foot and a palpable mass below the right costal margin | Pancreatic adenocarcinoma arising in LPH | |
| Siegler4 | 1 | 43 | M | Diffuse | Overwhelming pulmonary suppuration→Ex | Enlarged pancreas, replaced by fat; no visible exocrine portion, ducts, and islet tissue | |
| Nakamura et al9 | 1 | 43 | M | Body and tail | Abdominal mass | Marked fatty infiltration with scattered atrophied acinar cells associated with multiple cysts | |
| Okumura et al20 | 1 | 5 | F | Diffuse | Bannayan syndrome | Generalized subcutaneous lipomatosis, megalencephaly, and macrodactyly | Diffuse lipomatosis in the thoracic and abdominal cavity, and infiltration of fat tissue to the pancreas |
| Lozano et al27 | 2 | 25; 63 | F; M | N/A | Weight loss and massive steatorrhea | Lipomatosis of pancreas | |
| Henkinbrant et al3 | 1 | 70 | M | Diffuse | Abdominal pain, jaundice | Obstruction of the common bile duct | Enlarged pancreas, atrophy of the acinar lobules and the islets of Langerhans with marked fatty infiltration of the pancreas |
| Yoshimura et al10 | 1 | 38 | M | Diffuse | Juvenile Parkinson disease | Enlargement of the pancreas due to massive fat replacement; the exocrine glandular elements showed marked atrophy and loss, whereas the islets were preserved; the liver exhibited a histology mimicking alcoholic hepatitis with diffuse Mallory bodies; the nervous system showed diffuse Lewy bodies | |
| Bom et al19 | 1 | 18 | F | Diffuse | Shwachman syndrome | Pancytopenia, short stature, recurrent infections | Pancreatic lipomatosis |
| MacMaster and Cummings12 | 1 | 34 | N/A | Diffuse | Shwachman syndrome | Pancreatic lipomatosis | |
| Shimizu et al23 | 1 | 49 | F | Body and tail | Epigastric pain, jaundice | Fatty replacement of the pancreatic body and tail associated with leiomyosarcoma in the pancreatic head | |
| Sasaki et al2 | 1 | 52 | F | Diffuse | Chronic hepatitis B | Cirrhosis→Ex | Massive fatty replacement of pancreas |
| Maunoury et al13 | 1 | 19 | M | N/A | Johanson-Blizzard syndrome | Pancreatic lipomatosis | |
| Bralet et al8 | 1 | 68 | F | Diffuse | Diabetes mellitus type 2, left upper abdominal pain, and weight loss | Massive fatty replacement of pancreas with coexisting squamous cell carcinoma | |
| Belkind-Gerson et al22 | 1 | 14 | F | N/A | Shwachman-Diamond syndrome | Neutropenia, short stature, skeletal abnormalities→Ex | Pancreatic lipomatosis |
| Kuroda et al1 | 1 | 80 | M | Diffuse | Hepatitis B | Cirrhosis→Ex | Massive fatty replacement of pancreas |
| Flohr et al5 | 1 | 32 | M | Head | Primary sclerosing cholangitis, cirrhosis | LPH |
N/A indicates not available.