Fig. 4.

Rats were subjected to 90 min of MCAO. Six hours after reperfusion onset, they were treated with intra-arterial vehicle or 225 μg/kg MnTnHex-2-PyP. MnTnHex-2-PyP (225 μg/kg) was given subcutaneously twice daily for 7 days after which neurologic function was assessed. Circles indicate individual animal values. A, neurologic scores at 7 days after MCAO. Horizontal lines indicate group median values. 0 = no neurologic deficit. B to D, total cerebral, cortical, and subcortical infarct volumes, respectively, measured 7 days after MCAO. Horizontal lines indicate group mean values.