TABLE 1.

Redox characteristics of MnPorphyrins (metal-centered reduction potential, E_1/2) (Batinic-Haberle et al., 2010a), their reactivity toward O₂^⨪ (as described by rate constant for the catalysis of O₂^⨪ dismutation, log k_cat) (Batinic-Haberle et al., 2010a), and ONOO⁻ (as described by the rate of ONOO⁻ reduction, log k_red) (Batinic-Haberle et al., 2010a), and mouse brain concentrations

Dose corrected values are normalized to 1 mg of drug per kg body weight. Reference values are given for native SOD E_1/2 (Vance and Miller, 1998) [log k_cat(O₂^⨪)] (Goldstein et al., 2006) and the native ONOO⁻ reductase (its role in vivo is presumed based on the high rate constant), peroxiredoxin [log k_red (ONOO⁻)] (Trujillo et al., 2007). The log P_OW value is calculated using the equation log P_ow=0.96 × nC − 8.82, for MnTE-2-PyP, where nC is a number of carbon atoms in the alkyl chain. The experimentally determined value is provided for MnTnHex-2-PyP.

Compound	E1/2a	log kcat(O2⨪)	log kred(ONOO−)	log Pow	Brain	Dose Corrected Values
					nM
Native Cu-Zn SOD	∼+300	∼9.1	3.97b
Native peroxiredoxin			8.20
MnTE-2-PyP	+228	7.76	7.53	−6.89	11c	1.1
MnTnHex-2-PyP	+314	7.48	7.11	−2.76	19d	9.5

^a E_1/2 relates to Mn(III)P/Mn(II)P redox couple.

^b Alvarez et al. (2004).

^c MnTE-2-PyP mouse brain concentrations 24 h after a single 10 mg/kg i.p. injection (data previously reported in Spasojevic et al., 2008).

^d MnTnHex-2-PyP mouse brain concentrations 24 h after a single 2 mg/kg i.p. injection (5-fold lower dose; see Materials and Methods and Results).