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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Semin Nephrol. 2010 Sep;30(5):468–476. doi: 10.1016/j.semnephrol.2010.07.004

Figure 2. The complex Interaction between Genotype and Phenotype Development.

Figure 2

During normal development somatic cells that descended from a single progenitor, and contain similar genotype, differentiate to acquire diverse biological function by expressing and repressing different set of genes via establishing new epigenetic marks. While the genotype of an individual does not change hyperglycemia, uremia, different dietary and environmental factors might change the epigenome of cells leading to differences in gene and protein expression. Differences in the epigenotype might be response for the different (including disease) phenotype development. While the genotype is stable there is a more dynamic link between environmental factors and phenotype development.