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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Anticancer Drugs. 2011 Oct;22(9):905–912. doi: 10.1097/CAD.0b013e3283484750

Figure 4. PTEN Reconstitution alters cell responses to anti-HGF therapeutics in orthotopic glioma xenografts.

Figure 4

Animals bearing U87-tetPTEN intracranial xenografts were treated ± doxycycline (2 mg/mL in drinking water) for 6 days with either anti-HGF or control mAb 5G8 (1.25mg/kg i.p.) for 6 days. Intracranial tumor xenograft sections were analyzed for tumor volume (A), cell proliferation (B), angiogenesis (C), and apoptosis (D) as described in Materials and Methods. *** = P < 0.001 compared to controls, * = P < 0.05 compared to controls, L2G7 alone or Doxy alone ** = P < 0.01 compared to control, L2G7 alone or Doxy alone