Table 6.

Drugs used for the short-term prophylaxis and treatment of acute attacks of hereditary angioedema.

Short-term prophylaxis	Trade name	Dose	Adverse events
Tranexamic acid	Transamin®Hemoblock®	1 g administered orally every 4 h (or 0.5 g administered intravenously every 4 h) for 18 h	Diarrhea
High-dose attenuated androgens	DanazolOxandrolone	10 mg • kg−1 • day−1 with a maximum dose of 600 mg/day for 3-5 days before the procedure	Weight gain, voice changes, increased hair growth, and menstrual irregularity
C1-INH concentrate*and recombinant  C1-INH*	Berinert®Cinryze®	500-1,000 U on the day before the procedure or on the day of the procedure	-
Fresh plasma	-	10 ml/kg	Hyperosmolarity

Treatment of acute attacks
C1-INH concentrate*and recombinant C1-INH*	Berinert®Cinryze®	1,000 U administered intravenously or 10-20 U/kg	-
Fresh plasma	-	10 ml/kg	Hyperosmolarity
Bradykinin receptor Antagonist	Icatibant (Firazyr®)	30 mg/dose and repeat an initial dose and a second dose if the attack persists	Local hyperemia
Kallikrein inhibitor*	Ecallantide (Kalbitor®)	20 U/kg or 30 mg/dose and repeat the second dose if the attack persists	Hypersensitivity reactions

^*Drugs that have not yet been approved in Brazil.