Table 2.

CDKN2 and TP53 mutations in myoinvasive TCCs

Sample code	CDKN2/p16	TP53
97-1	homozygous deletion	wild type
94-10	methylation and FS (exon 2, codon 74)	Wild type
96-1	homozygous deletion	mutant (exon 5, codon 175)
96-2	Wild type	Mutant (exon 7, codon 261, SM)
97-6	Wild type	Mutant (exon 5, codon 162)
92-1	Wild type	mutant (exon 5, codon 158)
		(exon 6, codon 224)
		(exon 7, codon 228)
		(exon 8, codons 280 and 294)

(FS) Frameshift mutation; (SM) splice mutation. CDKN2 alterations were detected by Southern analysis and genomic sequencing; TP53 alterations were detected by genomic sequencing.