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Pharmacogenomics-based dose initiation algorithm.14
| Factor | Dose adjustment |
|---|---|
| Base Dose | 5.67 mg/day |
| AGE (yrs) | − 0.05*(AGE-61) |
| WT (lbs) | + 0.01*(WT-191) |
| CYP2C9 (each *2) | − 1.04*(no. of *2) |
| CYP2C9 (each *3) | − 1.14*(no. of *3) |
| VKORC1 (GG) | + 1.85 |
| VKORC1 (AA) | − 2.33 |
CYP2C9 adjustments as compared to *1/*1
VKORC1 adjustments as compared to AG
Minimum dose 0.5 mg/day
