TABLE 5.

Serum Chemistry Values on Days 3 and 29 from Mice Treated with the AAV2-TF2.3w-hEpo Vector^a

	Day 3		Day 29
	Male	Female	Male	Female
Na+	158 ± 3	159 ± 2	153 ± 0.7*↑	155 ± 2
Ca2+	10.6 ± 0.4	10.4 ± 0.5	10.5 ± 0.3	10.5 ± 0.4
Glucose	130 ± 20	135 ± 15	136 ± 23	136 ± 21
Blood urea nitrogen	23.5 ± 3.4	20.9 ± 4.9	13.4 ± 2.9	21.8 ± 7.6
Creatinine	0.52 ± 0.28	0.64 ± 0.11	0.48 ± 0.1	0.69 ± 0.14
Creatine kinase	312 ± 196	283 ± 195	248 ± 142	452 ± 345
Lactate dehydrogenase	618 ± 116*↓	501 ± 133	471 ± 248	580 ± 101
Alanine aminotransferase	120 ± 38	124 ± 58	62 ± 29	56 ± 22
Alkaline phosphatase	77 ± 17	103 ± 16	117 ± 18	134 ± 18
Sorbitol dehydrogenase	38 ± 4*↓	53 ± 10	23 ± 5	43 ± 9
Amylase	1923 ± 211	1737 ± 432	1717 ± 166*↓	1715 ± 208
Albumin	3.82 ± 0.17*↓	4.1 ± 0.3	3.4 ± 0.2	3.9 ± 0.3
Total protein	6.6 ± 0.3	6.4 ± 0.6	5.9 ± 0.3	5.6 ± 0.3
Total cholesterol	196 ± 18	132 ± 18	163 ± 18	103 ± 12
Triglycerides	225 ± 67	159 ± 59	263 ± 116	144 ± 52
Bile acids	72 ± 12	159 ± 5	78 ± 25	82 ± 18*↑

Note. Any value shown to be statistically different (p < 0.05; using an ANOVA and Dunnett's test) from the corresponding control value is indicated by “*” with an arrow pointing up or down indicating the direction of the change. Na⁺ and Ca²⁺ (mequiv/l), all enzymes (U/l), albumin and total protein (g/dl), bile acids (μmole/l), and all other constituents (mg/dl).

^aThese data (mean values ± SD) were from animals treated with the highest dose of vector (2.5 × 10¹⁰ particles/gland; Group 7 in Table 1).