Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Sep 1;22(17):3206–3217. doi: 10.1091/mbc.E11-02-0145

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2011 Aoki et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

“ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society of Cell Biology.

PMC Copyright notice

FIGURE 6: — Model of mitophagy in yeast. The initial trigger-inducing mitophagy comes from mitochondria (such as mitochondrial damage) and/or the cellular environment (such as dramatic nutrient change and oxidative stresses). The initial trigger is through an unidentified mitophagy signaling pathway and it reaches kinase X, which is believed to be a Ser/Thr–specific protein kinase. This kinase phosphorylates Ser-114 and Ser-119 on Atg32. Phosphorylation of Atg32, especially phosphorylation of Ser-114, mediates the Atg11–Atg32 interaction. Atg11 recruits mitochondria to the PAS, where the autophagosome is generated to enclose the mitochondria. Hog1 and Pbs2 affect the mitophagy signaling pathway or affect kinase X.