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. 2011 Sep 1;22(17):3242–3252. doi: 10.1091/mbc.E11-05-0420

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© 2011 Maier et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 7: — In vivo activity of Hairless mutant constructs. Wild-type and mutant constructs as indicated were expressed in the thorax of the developing fly using the MS1096-Gal4 driver line. Effects of Su(H) and Hairless on bristle development were studied singly and in combination to assay for the formation of a repressor complex. Open arrows (missing bristles due to transformation of external to internal fate) and closed arrows (ectopic bristles or double shafts) point to Notch loss-of-function phenotypes, and arrowheads (loss of bristles, double sockets) point to Notch gain-of-function phenotypes. Compared to the control (A), overexpression of wild-type Su(H) causes typical Notch gain-of-function phenotypes affecting the majority of macrochaetae and microchaetae (B). (C) Overexpression of full-length Hairless HFL results in Notch loss-of-function phenotypes affecting most macrochaetae and many microchaetae. (D) Combined overexpression of HFL and Su(H) enhances this effect strongly, and bushes of bristles appear as a result of reduced lateral inhibition. Flies resulting from overexpression of either Hairless mutant H^LD (E) or H^ΔNT (G) have nearly wild-type phenotype. Moreover, in combination with Su(H) (F, H) the phenotypes are similar to the sole Su(H) overexpression (see B).