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. 2011 Sep 1;22(17):3263–3275. doi: 10.1091/mbc.E11-01-0020

FIGURE 13:

FIGURE 13:

Schematic overview of the RhoGDIα-mediated balance between RhoA and RhoC, resulting in modifications of the signaling pathway and leading to cancer cell growth and migration. (1) In basal condition, the activation of RhoA and RhoC is not sufficient to induce NAG-1 expression via ROCK. Cancer cells proliferate and migrate efficiently. (2) On RhoC silencing, the amount of RhoA-GDP stabilized by RhoGDIα and available for activation by specific GEF is increased. This leads to an enhanced level of RhoA-GTP, which drives NAG-1 gene expression via ROCK. RhoA overexpression induces a similar phenotype. The shift of the balance toward RhoA also inhibits cell migration but through an NAG-1–independent pathway.