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. 1997 Aug 15;11(16):2040–2051. doi: 10.1101/gad.11.16.2040

Figure 3.

Figure 3

 Freeze–crush-induced injuries result in impaired skeletal muscle regeneration of FGF-6 mutant mice. Paraffin sections from wild-type (A,C,E) and FGF-6 mutant mice (B,D,F,G,H) were stained with HE (A–D) and according to the van Gieson procedure (E–H) after 4 days (A,B), 14 days (C–F), and 22 days (G,H) following injury. In wild-type mice well-advanced regeneration is visible after 4 days (A) and regeneration is complete after 14 days (C,E). In FGF-6 mutant mice a regeneration defect is already visible after 4 days B but is most striking at 14 days (D,F) and 22 days (G,H). In mutants, lesions contain large amounts of collagen that stain red in the van Gieson procedure and large amounts of fibroblastoid cells. After 3 weeks, damaged areas in mutants sometimes contain degenerated myotubes (G) or collagen deposits with large amounts of cells (H). In wild-type mice virtually no sign of the previous injury was detectable after 2 weeks (C,E). Magnifications, 200× (A–D) and 100× (E–H).