Figure 1. Notch receptor signaling.

A schematic view of two cells is shown, one expressing the Notch receptor, and an adjacent cell expressing the Notch ligand Jagged. Upon ligand binding, Notch is cleaved to release the extracellular domain, which is then endocytosed along with the ligand. Further cleavage of the receptor by the γ-secretase complex releases the Notch intracellular domain (NICD). NICD then translocates to the nucleus and regulates gene transcription (see text for details).