Table 1.

Anti-proliferative activity of various sugar analogues.

Compound (IC50, µM)	R	R1	R2	R3	Anomer	X	Y	SKBr3	MCF-7	LNCAP-LN3	PC3-MM2
14a	A	OH	OH	H	β	H	CH3	6.23 ± 0.52a,c	2.56 ± 0.08a	3.59 ± 3.40b	NTb
15a	A	OH	OH	H	α	H	CH3	6.71± 0.80	42.56 ± 2.48	1.20 ± 0.83	12.88 ± 9.30
14b	A	OH	OH	H	β	H	OCH3	1.46 ± 0.46	17.46 ± 1.22	2.29 ± 1.25	10.72 ± 10.85
15b	A	OH	OH	H	α	H	OCH3	11.10 ± 0.43	10.85 ± 0.18	NT	NT
14c	A	OH	OH	H	β	OCH3	CH3	7.18 ± 0.20	9.50 ± 0.16	12.76 ± 5.12	24.03 ± 17.14
15c	A	OH	OH	H	α	OCH3	CH3	12.52 ± 0.54	64.51 ± 3.52	14.93 ± 9.24	25.37 ± 7.26
17a	A	OH	H	H	β	H	CH3	>100	>100	3.75 ± 0.01d	10.05 ± 0.01d
18a41	A	OH	H	H	α	H	CH3	>100	>100	7.34 ± 11.82	NT
20a	A	H	OH	H	β	H	CH3	>100	>100	3.11 ± 2.58	>100
21a41	A	H	OH	H	α	H	CH3	9.28 ± 0.04	11.20 ± 0.49	8.56 ± 9.00	NT
20b	A	H	OH	H	β	H	OCH3	8.75 ± 0.49	95.77 ± 3.21	11.50 ± 5.66	NT
20c	A	H	OH	H	β	OCH3	CH3	>100	>100	1.49 ± 0.51	1.24d
21c	A	H	OH	H	α	OCH3	CH3	1.37 ± 0.14	>100	3.27 ± 0.09d	2.35 ± 1.11
23a	A	OH	OH	CH2OH	β	H	CH3	9.59 ± 0.42	11.07 ± 0.47	3.23 ± 3.76	4.58 ± 2.78
23b	A	OH	OH	CH2OH	β	H	OCH3	11.76 ± 0.06	14.34 ± 0.16	6.78 ± 2.25	17.94 ± 10.33
23c	A	OH	OH	CH2OH	β	OCH3	CH3	9.45 ± 0.19	3.37 ± 0.06	4.66 ± 1.48	5.90 ± 2.58
25a	B	OH	OH	H	β	H	CH3	12.46 ± 0.52	37.17 ± 1.68	3.65 ± 2.83	NT
25b	B	OH	OH	H	β	H	OCH3	7.57 ± 1.05	11.73 ± 0.78	2.60 ± 1.51	10.64 ± 20.83
25c	B	OH	OH	H	β	OCH3	CH3	9.45 ± 0.19	3.37 ± 0.07	4.72 ± 1.48	9.56 ± 2.58
27a	B	OH	H	--	β	H	CH3	>100	>100	NT	NT
28a	B	OH	H	--	α	H	CH3	>100	>100	5.34 ± 4.76	NT
30a	B	H	OH	--	β	H	CH3	35.24 ± 1.76	>100	3.72d	10.05 ± 6.75d
31a	B	H	OH	--	α	H	CH3	>100	>100	4.96 ± 10.58	26.79 ± 58.24
33a	C	OH	OH	--	β	H	CH3	2.38 ± 0.06	>100	>100	NT

^aValues represent mean ± standard deviation for at least two separate experiments performed in triplicate.

^bValues represent mean ± standard deviation from dose response curves for at least two separate experiments performed in duplicate.

^cAll error values listed represent 95% confidence intervals throughout the manuscript except where indicated

^dError values listed as standard deviations