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. Author manuscript; available in PMC: 2012 Jun 9.
Published in final edited form as: J Med Chem. 2011 May 9;54(11):3839–3853. doi: 10.1021/jm200148p

Table 2.

Anti-proliferative activity of cyclohexyl analogues.

graphic file with name nihms295690t2.jpg
Compound
(IC50, µM)		 R1 R2 X Y SKBr3 MCF-7 LNCAP-LN3 PC3-MM2
43a CH3 CH3 H CH3 >100a >100a 1.24 ± 0.17b,d 2.49 ± 1.70b
43b CH3 CH3 H OCH3 3.45 ± 1.73 1.56 ± 0.03 NT NT
43c CH3 CH3 OCH3 CH3 >100 >100 NT NT
44a H CH3 H CH3 >100 >100 1.14 ± 0.67 4.09 ± 1.63
44b H CH3 H OCH3 6.38 ± 0.71 8.52 ± 0.36 NT NT
44c H CH3 OCH3 CH3 >100 >100 NT NT
4541 H H H CH3 >100a >100 1.58 ± 0.75 4.04 ± 0.38d
45b H H H OCH3 7.44 ± 0.36 5.46 ± 0.36 NT NT
45c H H OCH3 CH3 8.18 ± 0.79 10.13± 1.04 NT NT
a

Values represent mean ± standard deviation for at least two separate experiments performed in triplicate.

b

Values represent mean ± standard deviation from dose response curves for at least two separate experiments performed in duplicate.