Table 3. Structure–activity relationship of meso-bicyclic ether P2 ligands.
| Compound Ligand number |
Ki (nM) |
IC50 (nM) |
|
|---|---|---|---|
| 24 |
|
0.11 | 3.8 |
| 25 |
|
0.18 | 210 |
| 26 |
|
0.51 | 380 |
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