Figure 4.

Macrochaete defects in mus304 adults. (A) The genetic basis of bristle defects due to genomic instability. Minute loci (M) are present throughout the genome and are haploinsufficient for macrochaete (bristle) development. If one of the two wild-type copies of a Minute locus is lost in a macrochaete precursor, the resulting macrochaete will exhibit a Minute phenotype. (B) A wild-type notum. Two specific macrochaetae are indicated (arrows). (C) A mus304 notum. The indicated macrochaetae exhibit a Minute phenotype (i.e., shorter and thinner). (D) The frequency of Minute bristles in different genetic backgrounds. Error bars, s.e.m..