Table 5.
KEGG pathways and PANTHER classifications associated with top 80 genes selected by BMI
| KEGG pathway name | p-value | Associated genes |
|---|---|---|
| Colorectal cancer | 1.3809E-4 | FOS, MSH2, APC |
| Pathways in cancer | 0.0019 | FOS, MSH2, APC, TCEB2 |
| Metabolic pathways | 0.0021 | ADH6, SAT1, EXT2, TGDS, BTD, PRPS1, AGPS |
| Biotin metabolism | 0.0032 | BTD |
| MAPK signaling pathway | 0.0094 | DUSP10, MAP2K4, FOS |
| Cytokine-cytokine receptor interaction | 0.0098 | CXCR4, ACVR2A, IL13RA1 |
| Toll-like receptor signaling pathway | 0.0117 | FOS, MAP2K4 |
| Tight junction | 0.0196 | PPP2R2 D, INADL |
| Mismatch repair | 0.0361 | MSH2 |
| Glycosaminoglycan biosynthesis - heparan sulfate | 0.0408 | EXT2 |
| Pentose phosphate pathway | 0.0423 | PRPS1 |
| Endocytosis | 0.0428 | ARAP1, CXCR4 |
| PANTHER classification | p-value | Associated genes |
| Oxidative stress response | 8.6417E-5 | TXN, MAP2K4, DUSP10 |
| O-antigen biosynthesis | 0.0064 | TGDS |
| T cell activation | 0.0083 | FOS, B2M |
| Interleukin signaling pathway | 0.0108 | IL13RA1, FOS |
| Apoptosis signaling pathway | 0.0133 | ATF3, FOS |
| FGF signaling pathway | 0.0135 | MAP2K4, PPP2R2D |
| Axon guidance mediated by Slit/Robo | 0.0253 | CXCR4 |
| Hypoxia response via HIF activation | 0.0408 | TXN |
| Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade | 0.0484 | FOS |