Table 6.
NCI-Nature pathway interactions associated with top 80 genes selected by BMI
| NCI-Nature Pathway Interaction | p-value | Associated genes |
|---|---|---|
| ATF-2 transcription factor network | 6.8276E-5 | ATF3, FOS, DUSP10 |
| Downstream signaling in naïve CD8+ T cells | 1.8173E-4 | B2 M, EGR1, FOS |
| Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) | 2.6255E-4 | EGR1, MAP2K4, APC |
| Ephrin B reverse signaling | 8.6116E-4 | CXCR4, MAP2K4 |
| ErbB1 downstream signaling | 8.7013E-4 | MAP2K4, FOS, EGR1 |
| Regulation of p38-alpha and p38-beta | 0.0011 | DUSP10, MAP2K4 |
| Direct p53 effectors | 0.0013 | APC, MSH2, ATF3 |
| Trk receptor signaling mediated by the MAPK pathway | 0.0014 | EGR1, FOS |
| RhoA signaling pathway | 0.0021 | FOS, MAP2K4 |
| IL6-mediated signaling events | 0.0023 | MAP2K4, FOS |
| Presenilin action in Notch and Wnt signaling | 0.0024 | FOS, APC |
| Calcineurin-regulated NFAT-dependent transcription in lymphocytes | 0.0025 | EGR1, FOS |
| Regulation of Androgen receptor activity | 0.0027 | EGR1, MAP2K4 |
| Fc-epsilon receptor I signaling in mast cells | 0.0041 | FOS, MAP2K4 |
| IL12-mediated signaling events | 0.0045 | B2 M, FOS |
| HIF-1-alpha transcription factor network | 0.0052 | FOS, CXCR4 |
| CDC42 signaling events | 0.0058 | APC, MAP2K4 |
| Regulation of nuclear SMAD2/3 signaling | 0.0075 | FOS, ATF3 |
| Glucocorticoid receptor regulatory network | 0.0077 | FOS, EGR1 |
| Sumoylation by RanBP2 regulates transcriptional repression | 0.0174 | RANBP2 |
| JNK signaling in the CD4+ TCR pathway | 0.0206 | MAP2K4 |
| Ras signaling in the CD4+ TCR pathway | 0.0222 | FOS |
| Hypoxic and oxygen homeostasis regulation of HIF-1-alpha | 0.0284 | TCEB2 |
| Cellular roles of Anthrax toxin | 0.0346 | MAP2K4 |
| VEGFR3 signaling in lymphatic endothelium | 0.0361 | MAP2K4 |
| S1P2 pathway | 0.0377 | FOS |
| PDGFR-alpha signaling pathway | 0.0377 | FOS |
| ALK1 signaling events | 0.0392 | ACVR2A |
| Signaling events mediated by PRL | 0.0392 | EGR1 |
| TRAIL signaling pathway | 0.0438 | MAP2K4 |
| Regulation of CDC42 activity | 0.0453 | APC |
| S1P3 pathway | 0.0453 | CXCR4 |
| CD40/CD40L signaling | 0.0469 | MAP2K4 |
| Canonical Wnt signaling pathway | 0.0469 | APC |
| p38 MAPK signaling pathway | 0.0469 | TXN |
| Calcium signaling in the CD4+ TCR pathway | 0.0484 | FOS |
| Nongenotropic Androgen signaling | 0.0484 | FOS |
| Nephrin/Neph1 signaling in the kidney podocyte | 0.0499 | MAP2K4 |
| IL12 signaling mediated by STAT4 | 0.0499 | FOS |